Dziembowski Lab

Research focus

ERC Advanced Grant · 2022

Principles of endogenous and therapeutic mRNA turnover in vivo

During the COVID-19 pandemic, we witnessed the application of mRNA vaccines for SARS-CoV-2, paving the way for the widespread use During the COVID-19 pandemic, we witnessed the application of mRNA vaccines for SARS-CoV-2, paving the way for the widespread use of therapeutic mRNAs in medicine. However, lack of knowledge regarding mRNA metabolism in vivo limits the optimization and refinement of such therapies. Our preliminary data, acquired via Direct RNA Sequencing (DRS), shows that variability of poly(A) tail length and, therefore, stability of endogenous and therapeutic mRNAs in different tissues and cell types is much larger than previously thought. Here, we propose the ViveRNA project,…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.