ERC Advanced Grant · 2022
HOst-Transposon Interactions in the MAle GErmline
Transposable elements (TEs) are mobile DNA sequences that have massively colonized mammalian genomes. Host genomes and TEs are engaged in ambiguous trade-offs, whereby TEs can be co-opted for genomic upgrades over evolutionary timescales, but they should also be suppressed to protect genome stability and function. Effective and multi-layered surveillance is primordial: TE reactivation is associated with various dysfunctional states, including infertility, ageing, cancer or neurological disorders, involving both transposition-dependent or -independent routes. Understanding the two-way relationship between host genomes and their TE integrants is an essential and fascinating topic, with…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.
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