ERC Consolidator Grant · 2022
High throughput phylogeography of tumors: how the tissue environment influences cancer evolution?
The tumor microenvironment (TME) is a dynamic ecosystem wherein tumor cells, immune cells and stromal cells interact and evolve. One of the primary characteristics of cancer progression is the diversification, selection and expansion of tumor sub-clones in manner that largely depends on the TME, e.g., through immune responses or metabolic crosstalk. Advances in single-cell and spatial genomics provide exciting opportunities for studying how tumors evolve in their tissue context, by lending an information-rich perspective on which cell subsets are present and how they might interact. However, fundamental questions, which require the knowledge of how single tumor cells are related…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.