ERC Starting Grant · 2022
Studying the cis-regulatory changes that have shaped human evolution
While the phenotypes that set us apart from our closest extinct and extant relatives have been largely demarcated, we are still far from understanding the genetics of human adaptation, and how these changes affect our current anatomy, physiology, and health. Most human adaptations have likely occurred in regulatory regions, particularly in cis-regulatory elements, such as promoters and enhancers. However, our ability to study cis-regulatory evolution is limited due to the complexity of identifying cis-regulatory changes and linking them to phenotypes. We believe these limitations can now be tackled by merging several cutting-edge approaches, primarily hybrid cells and massively parallel…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.