ERC Starting Grant · 2022
Proteome-wide Functional Interrogation and Modulation of Gut Microbiome Species
The gut microbiome plays a key role in human health. Genomics approaches excel at cataloguing species composition, and associating imbalances with disease. Yet, as we are oblivious to the function of a large proportion of proteins of these organisms, we are limited in our understanding of the molecular mechanisms that drive disease or promote health. In this groundbreaking project we will systematically identify the function and interactions of proteins of microbiome species, deliver compounds to modulate them, and develop strategies to rationally manipulate microbiome composition. We will use a scalable systems biology approach based on high-throughput proteomics, using more than 100 drugs…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.