Zimmermann Lab

European Molecular Biology Laboratory (EMBL)

Baden-Württemberg (DE1) · Germany

ERC-funded
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Research focus

ERC Starting Grant · 2022

Gut microbiota drug biotransformation as a tool to unravel the mechanisms of metabolic microbiota-host interactions

The variability of the human gut microbiome (entirety of microorganisms inhabiting the intestine) far exceeds human genome variability, and has been connected to various aspects of human health. Although microbiome differences are often linked to altered metabolism, the current view on metabolic interactions between the microbiota and the host remain mostly descriptive due to several limiting factors. First, most sequencing-based human microbiome studies rely on correlative analyses between microbiome composition and human phenotypes, depend on largely incomplete microbial genome annotations, and are not targeted to identify community-mediated functional traits. Second, many metabolites can…

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