ERC Starting Grant · 2022
The evolution and function of fish TRIM E3 ubiquitin ligases
FishTRIM aims to study the evolution and function of the TRIM family of E3 ubiquitin ligases in fish. This family has undergone several clade-specific expansions across the fish phylogeny, with single-copy mammalian TRIMs frequently present in large numbers in fish genomes. TRIM E3 ligases and their direct interactions with viral proteins are key in host-pathogen relationships, and several fish TRIMs have been associated to antiviral responses. Additionally, positive selection has been observed in fish TRIM protein domains involved in protein-protein interactions and pathogen recognition. This suggests that this family of fish E3 ubiquitin ligases may act as an immune mechanism against…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.