ERC Starting Grant · 2022
Uncovering the missing X factors to understand sex bias in cardiovascular disease
Cardiovascular diseases (CVD) occur and progress differently in men and women, and the risk dramatically increases with age. Hormone differences have been suggested to account for the sex difference by observing that younger women are regularly protected from CVD until post-menopause. However, hormone replacement therapies failed to provide cardioprotection, suggesting that other biological factors contribute to sex disparities in CVD development. Other likely contributors to sex bias are genes that escape female X chromosome inactivation, an understudied epigenetic phenomenon that has so far not been linked to sex differences in CVD. These so-called escaper genes have twice the gene dose…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.