ERC Advanced Grant · 2023
Deep genetics to study and uncover ‘hidden’ biology
Human genes are organized in complex networks, to produce thousands of proteins to perform a myriad of functions. Whereas we have detailed maps for most biochemical pathways, the wiring of genetic networks in human cells is poorly understood. Development of powerful human genetic tools (CRISPR, RNAi, haploid cells), to which I made crucial contributions, have proven invaluable to study genetic networks. However, they face two major limitations. First, they provide information at the gene level, whereas it will be much more informative to understand genetic regulation at the level of protein domains or individual amino acids. Second, important biology can be masked – for example, by the cell…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.