ERC Advanced Grant · 2023
Lysine Acetylation: The Scope and Function in Gene Activation
Transcription, the first and most crucial step in decoding the genome, is orchestrated by an extensive repertoire of transcription factors (TFs). TFs transmit diverse signals to the nucleus, directing precise temporal and spatial gene activation programs. Remarkably, to execute TF cues, all cells utilize the same RNA polymerase II machinery to transcribe protein-coding genes. It remains a big mystery how highly diverse TFs manage to recruit the same general transcription machinery. I contend that TF cues are first converted into a generic signal, which is then interpreted and acted upon by the general transcription machinery. ACT-SIGNAL will examine if the lysine acetyltransferases (KATs)…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.