Ridder Lab

University Medical Center Utrecht

West-Nederland (NL3) · Netherlands

ERC-funded
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ERC Consolidator Grant · 2023

Foundation models for molecular diagnostics - machine learning with biological ‘common sense’

Molecular diagnostics is crucial in fulfilling the promise of personalized medicine. While we are amidst an AI revolution, current machine learning models (ML) struggle to effectively learn from molecular (‘omics’) patient profiles and fail to make robust predictions. Perhaps this is not a surprise. After all, molecular disease biology is immensely complex, and we ask ML models to predict such complicated things as patient prognosis, without them ‘knowing’ anything about molecular biology and based on limited training data. To address this, I will create foundation models on top of the vast troves of available biomolecular data, such as multi-omics profiles in healthy and diseased tissues,…

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