Stelzer Lab

Weizmann Institute

- · Israel

ERC-funded
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Research focus

ERC Consolidator Grant · 2023

How do cells form an embryo: Intracellular, temporal, and phenotypic dissection of mammalian gastrulation

In multicellular orIn multicellular organisms, how variation is achieved while cells comprise identical genetic information represents a fundamental open challenge my group strives to engage in the coming years. The development of a single fertilized egg into a complete embryo represents an especially beautiful embodiment of this problem. The process of differentiation is defined by the capacity of the cell ensemble to acquire increasingly more specialized internal states in a coordinated fashion. We are therefore excited by recent breakthroughs in single-cell transcriptomics and epigenomics since these can capture the emergence of embryonic cellular diversification at incredible…

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