ERC Consolidator Grant · 2023
The “oncogenic shock” model has been introduced to describe the interplay between pro-survival and pro-apoptotic signals that follow an oncogene's inactivation and lead to cancer cell death. In my recent work, I demonstrated that identifying novel cancer dependencies through systematic computational analyses of CRISPR functional genetic screens and multi-omic data is an excellent means to discover and prioritise new anti-cancer therapeutic targets. Here, I extend the oncogenic shock concept to any cancer dependency gene. I call “cancer dependency shock” (DepSHOCK) the signal dynamics’ interplay that follows the ablation of any gene essential for cancer cell survival, i.e., cancer dependency…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.