Dar Lab

Weizmann Institute

- · Israel

ERC-funded
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ERC Starting Grant · 2023

Visualizing microbial societies: exposing the principles of single-cell phenotypic heterogeneity via massively multiplexed imaging

Bacteria are social organisms that interact and coordinate their behaviors to shape our world. Whereas their clonal populations are genetically identical, they contain phenotypically distinct members. This diversity provides resilience to unpredictable environmental changes, such as antibiotic exposure or nutrient depletion. It also facilitates cooperative interactions between different sub-population via specialization in costly activities such as virulence factor production, forming an extended basis for sociality. Yet, the phenotypic landscape in any given species remains largely unexplored due to the technical challenges of profiling individual bacteria, particularly in spatially…

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