ERC Advanced Grant · 2024
Uncovering the hidden origin behind the missing heritability
Understanding the genetic causes of phenotypic diversity in natural populations is a major challenge. While advances have been made in identifying the genetic basis of complex traits, our knowledge remains incomplete. Whole-genome sequencing has enabled genome-wide association studies (GWAS) to link genetic variants to traits, including human diseases. However, even with thousands of causal variants identified, they often account for only a small fraction of phenotypic variation. Uncovering the sources of this "missing heritability" is essential for predicting complex traits from genome sequences. The sources of missing heritability are largely unknown but may include: (i) incomplete…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.