ERC Advanced Grant · 2024
Sensing of cytoplasmic double-stranded RNA in plants
Elimination of foreign nucleic acids is key to host survival and reproduction. Long double-stranded RNA (dsRNA) in the cytoplasm is used to distinguish viral from host genetic material, and several metazoan dsRNA receptors elicit innate immune responses upon binding to dsRNA. Plants are thought to rely exclusively on RNA interference (RNAi) to eliminate RNA with double-stranded features. Two DICER-LIKE (DCL) enzymes, DCL4 and DCL2, act redundantly to cleave dsRNA into small interfering RNAs that in turn program RNA Induced Silencing Complexes to silence viral RNA using base pairing as specificity determinant. Our recent work shows that this view of plant innate antiviral immunity is…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.