ERC Advanced Grant · 2024
Antibody-guided design of multivalent nanoparticle vaccines against bacterial pathogens
Vaccines are the most effective single measure to protect populations against infectious diseases without promoting antimicrobial resistance (AMR). In this proposal, I intend to harness the rapid developments in protein design and quantitative and structural mass spectrometry to i) enable detailed molecular characterization of circulating serum antibody repertories, ii) establish a generalizable framework for antibody-guided design of next-generation nanoparticle vaccines against bacteria and iii) use the developed nanoparticle vaccines to investigate structural properties of protective antibody responses required for immunity. The planned work relies on identifying and producing protective…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.