ERC Advanced Grant · 2024
Dimensionality of the human phenome
What am I going to do? I will use data from millions of human genomes and thousands of traits (the “phenome”) to quantify the dimension of the heritable human phenome and dissect and map it to single DNA variant resolution; use whole genome sequence data in populations and families to estimate mutational trait heritability; predict future phenotypes using millions of DNA variants and thousands of environmental factors. Why am I going to do this? Despite the discovery of hundreds of thousands of DNA variants that are statistically associated with one or more human complex traits, we do not know which variants are causative, how many traits they affect (pleiotropy), how they function and why…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.