ERC Consolidator Grant · 2024
Heterochromatin repair: mechanisms and roles across scales
Cells face continuous challenges from insults that damage their DNA. To safeguard DNA integrity, a range of repair mechanisms have evolved, which are crucial for organismal survival. However, the eukaryotic nucleus contains different chromatin domains, each requiring specific repair mechanisms to ensure genome stability. In particular, the compact and transcriptionally silenced heterochromatin domains, which are riddled with repetitive DNA and developmental genes, are a challenging environment to repair DNA damage. Despite covering a substantial amount of our genome and being essential for organismal viability and development, heterochromatin remains poorly understood in its response to DNA…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.