ERC Consolidator Grant · 2024
Genome Enhancer Network Exploration – Tuning expression through enhancer collaboration
Enhancers are the central regulators of temporal and spatial gene expression patterns, but how enhancers control their target genes from vast distances remains enigmatic. Individual enhancers do not work in isolation but are embedded into the genomic context, often together with other enhancer elements. The synergy arising from multiple enhancers can activate a target gene across distances that the individual elements cannot bridge. Therefore, the synergy of enhancers plays an essential role in gene regulation, but the nature of this synergy and how it affects gene expression is not understood. We have recently established a unique synthetic platform that allows for the efficient…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.