ERC Consolidator Grant · 2024
Unraveling the regulation of crossover formation from its in vivo dynamics
The formation of crossovers during meiotic cell divisions is a crucial process to produce sperm and egg cells. This mechanism not only secures proper chromosome segregation but also enhances genetic diversity, playing an essential role in sexual reproduction and evolutionary adaptation. Disruptions in the regulation of crossover events can have detrimental effects on individual organisms and entire species populations. Thus, crossover formation is tightly regulated by both positive and negative pathways. Crossover assurance guarantees that each pair of homologs undergoes at least one crossover, facilitating proper segregation. Simultaneously, crossover interference prevents individual…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.