ERC Consolidator Grant · 2024
Chromosomal instability (CIN) is a main cause of tumor heterogeneity, tumor evolution and therapy resistance of cancers. Chromosomally instable gastric cancer (CIN-gastric cancer) accounts for 50-70% of gastric tumors and is the poorest prognosis tumor subtype with the most suppressed tumor immune microenvironment. However, it is not understood how CIN contributes to poor prognosis and edits the tumor immune response of CIN-gastric cancer, due to a lack of assays investigating native CIN-driving mechanisms at the single cell level. I invented a pioneering, microscopy-based functional single cell sequencing method, which enables selective profiling of rare subpopulations of cells displaying…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.