ERC Starting Grant · 2024
Why do transcription factors bind what they bind when they bind?
Transcription factor binding is orchestrated by a complex interplay between DNA sequence, chromatin composition, protein interactions, and transcription factor concentration. These regulatory features determine the binding kinetics: how long it takes for a certain amount of transcription factor to associate, and subsequently dissociate from specific binding sites. These kinetics are in turn determined by the thermodynamic properties of each interaction. It is currently not possible to measure the biochemical kinetics of transcription factor binding across the chromatinized genome inside the nucleus of a cell. To understand why a transcription factor binds to a specific…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.