ERC Starting Grant · 2024
Unraveling Ribosome Heterogeneity: Implications for Metastasis and Beyond
Protein translation, considered a mere reflection of transcription, emerges as a regulatory hub, shaping proteomes and directing cellular outcomes. This is due to existence of heterogeneous ribosome populations, yielding specialized ribosomes that drive context-dependent translation. While technological advances enable mapping of ribosomal diversity, questions remain as to the prevalence of the phenomenon and the mechanisms by which specialized ribosomes confer specific functions. Studies propose the presence of onco-ribosomes promoting oncogenic translational programs and regulating disease-related functions. Metastasis, the deadly spread of cancer cells to remote organs, is a key process…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.