ERC Starting Grant · 2024
Mutation rate determinants across cellular and evolutionary scales
As individuals age, mutations accumulate inexorably in their cells, playing a key role in evolution, ageing, and disease. Despite their importance, we still have a poor understanding of how mutations originate, or why some cells accumulate more mutations than others. This proposal aims to address these fundamental questions by examining two axes of mutation rate variation: among cell types and across species. In Aim 1, we will decode the rules of germline mutation during mammalian spermatogenesis. Cells in the germline exhibit mutation rates significantly lower than those in the soma, through mechanisms that remain unknown. Leveraging recent breakthroughs in long-read DNA sequencing, we…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.