ERC Starting Grant · 2024
Deciphering the regulatory logic of the ubiquitin system
As the primary route through which eukaryotic cells achieve selective protein degradation, the ubiquitin-proteasome system (UPS) plays a key role in virtually all critical cellular processes. A major unresolved question concerns how the ubiquitin system attains such high selectivity towards its myriad of substrates. The main specificity determinants are the E3 ubiquitin ligases, which recognise cognate ‘degron’ motifs found in substrate proteins. However, for the majority of the ~600 E3 ligases encoded in the human genome we still have little or no knowledge as to their substrates, and our understanding of degron motifs remains limited. This knowledge gap prevents us from appreciating how…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.