Bakshi Lab

University of Cambridge

- · United Kingdom

ERC-funded
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ERC Consolidator Grant · 2025

Systems Analysis of The Physiological Determinants of Phage Infection Dynamics

Bacteriophages (phages) are viruses that infect and kill bacteria, playing a crucial role in shaping microbial communities. They are also emerging as precision tools for combating antibiotic-resistant bacteria, targeted biocontrol, and microbiome modulation. As obligate parasites, phages rely on the physiological state of their bacterial hosts to progress through infection stages. However, the mechanisms by which host physiology affects the success of phage infection within cells and how host variability impacts phage effectiveness in eradicating bacterial populations remain poorly understood. This knowledge gap limits our ability to predict phage performance across environments and…

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