Quadrana Lab

National Centre for Scientific Research (CNRS)

Ile-de-France (FR1) · France

ERC-funded
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Research focus

ERC Consolidator Grant · 2025

Interplays and evolutionary dynamics of transposable elements and host proteins

Transposable elements (TEs) are mobile genetic elements capable of self-replication and integration into new genomic locations, influencing the evolution of genome architecture and function. While their core mobilization machinery is highly conserved across eukaryotes, TEs also exhibit extraordinary potentials to encode a diversity of auxiliary proteins and protein domains, which contribute to complex interactions with host-encoded factors. Yet, the extent to which these interactions shape TE diversification and propagation remains poorly understood. In HosTEome we aim to determine the mechanistic and evolutionary interplay between TE-encoded and so called “host” proteins. Building on our…

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