ERC Starting Grant · 2025
Unraveling the network that controls the fate of RNA Polymerase II during early elongation.
The repertoire of messenger RNAs (mRNAs) in a cell dictates cell identity and function. Therefore, mRNA expression is tightly controlled. A previously underappreciated regulatory step is early transcription termination, which can abort the synthesis of full-length mRNAs. The early termination of many non-coding RNAs prevents transcriptional interference and genomic instability. Thus, cells need to correctly balance early termination and productive elongation at both coding and non-coding loci. Why elongation is favoured at some loci, and termination at others, is poorly understood. To understand how the balance between elongation and termination is achieved, we need to know what sequence…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.