ERC Starting Grant · 2025
Genome editing of noncoding regions to map sequence-function relationships at scale
Deciphering how genetic variants lead to disease can advance precision diagnostics and mechanistically informed therapies. Yet, our ability to link variants in the human genome’s vast noncoding regions to phenotypic consequences is highly limited. This stems largely from a lack of experimental evidence on individual variants’ functional effects. Here, we propose to develop and deploy a suite of new genome editing methods to generate functional data for noncoding variants at unprecedented scale. First, we will leverage a prime editing screening platform we have recently established to systematically ask how intronic variants and 5’-untranslated region (5’UTR) variants lead to loss of…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.