Manno Lab

Research focus

ERC Starting Grant · 2025

Cell decision capture and control via joint Raman live and omics profiling

The developing nervous system generates an extraordinary diversity of cell types through a series of critical fate decisions made by neural progenitors. Despite recent progress in cataloging the heterogeneity of brain cells, we lack an understanding of the factors orchestrating their fine specification, especially in humans. As a result, many decision processes have uncharacterized determinants and are accounted for as stochastic, leaving us without control over them. This knowledge gap stems from the absence of a systematic approach to capture dynamic moments of cell decision-making and discover the factors controlling them. I hypothesize that most fate decisions in the human developing…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.