ERC Starting Grant · 2025
Epigenome Maintenance on Sister Chromatids
DNA replication not only involves the copying of the genome to propagate cell identity to daughter cells but also of the epigenome, where histones and their post-translational modifications (PTM) are accurately maintained in replicated chromatin. This is achieved by a strikingly coordinated process that ensures accurate, symmetric recycling of H3-H4 tetramers to both daughter strands, thus forming the basis of epigenetic memory. Recently, I identified H2A-H2B PTMs to be also symmetrically recycled in a H3-H4-independent manner. The underlying mechanism and their role in epigenetic memory remain unclear. Moreover, whether the asymmetric nature of DNA replication (leading vs. lagging strand)…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.