ERC Starting Grant · 2025
Decoding and perturbing cell identity regulatory network for cell fate and state engineering
Human cells engineered in vitro have revolutionized our ability to model human biology and diseases, offering exciting opportunities for therapeutic screening and intervention. However, single-cell transcriptomics (scRNA-seq) reveals that engineered cells often remain heterogeneous, immature, and dissimilar to primary counterparts. Precise cell engineering remains challenging without systematic interrogation of gene regulatory networks (GRNs) that establish cell identity. Here, we propose to engineer precise cell fates and states by coupling GRN decoding, perturbation screening, and single-cell technologies. Our vision is to decode GRNs that shape cell identities in fate specification,…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.