ERC Starting Grant · 2025
Clonal hematopoiesis in cancer
Clonal hematopoiesis (CH) is the expansion of somatically mutated hematopoietic stem cells. Clonal hematopoiesis of indeterminate potential (CHIP) occurs when CH is driven by mutations in myeloid driver genes in individuals without hematologic disorders. CHIP increases the risk of hematological malignancies and chronic inflammatory diseases. CHIP is also associated with a higher incidence of non-hematological malignancies, such as lung cancer. These associations underline the importance of CHIP in the development of both malignant and non-malignant diseases. Patients with cancer have higher prevalence of CHIP compared to the general population and are at risk of developing therapy-related…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.