ERC Advanced Grant · 2016
Encapsulated eukaryotic ribosome assembly
The production of fully functional ribosomes is vital for every cell, with failure causing human diseases called ribosomopathies. Eukaryotic ribosome assembly is catalyzed by ~200 assembly factors that guarantee efficient and accurate production of ribosomal subunits along a temporally and spatially ordered pathway. About one third of these factors are utilized in the formation of the earliest biogenesis intermediate, termed 90S pre-ribosome or small subunit processome. Recent insight into the 90S structure from a eukaryotic thermophile, Chaetomium thermophilum, has provided a first spatial impression on this most sophisticated process, which includes co-transcriptional RNA folding and…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.