Crabbe Lab

Research focus

ERC Starting Grant · 2016

Nuclear envelope attachment and dynamics of Human telomeres - unravelling nuclear organization

The spatial and temporal organization of the nucleus and its components are essential for genome regulation. During interphase of mammalian cells the nuclear envelope maintains the shape and the mechanical integrity of the nucleus, but also provides an anchor for chromatin that is connected to its inner side. This interaction mediates the regulation of gene expression, DNA replication and the maintenance of genome stability. In human cells I found that a large subset of telomeres, the natural ends of linear chromosomes, are transiently anchored to the nuclear envelope specifically during postmitotic nuclear assembly. Chromatin organization undergoes extensive changes during progression…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.