ERC Consolidator Grant · 2022
Quantitative multimodal pulse-and-label time-resolved chromatin maps
Chromatin packages the eukaryotic genome in a highly dynamic fashion, with dramatic structural changes during every cell cycle. At the same time, chromatin provides remarkable stability for transcriptional regulation and genome organization, for example in maintaining gene expression programs and lineage identity during complex organismal development. A mechanism to propagate information through ‘disruptive’ transitions in the cell cycle, namely DNA replication and mitosis, is key in maintaining heritable, so-called ‘epigenetic’ chromatin states. Proteins that build and interact with chromatin, foremost histones, are much more than static architectural components. This motivates the…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.