ERC Consolidator Grant · 2017
Discovery and molecular investigation of mycobacterial transporters responsible for iron acquisition
To infect humans, the devastating pathogen Mycobacterium tuberculosis critically depends on two closely related siderophores – soluble carboxymycobactin and membrane-bound mycobactin – which capture iron with high affinity inside the host cell. Despite their undisputed importance for virulence, little is known about how these siderophores are exported and imported across the two mycobacterial membranes. Building on my lab’s experience in elucidating transport processes of pathogenic bacteria, we will unravel the molecular mechanism of an unusual ABC exporter which is thought to import iron-loaded siderophores across the inner mycobacterial membrane and to release iron in the cytoplasm by…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.