ERC Starting Grant · 2017
Rag-independent regulation of mTOR by Amino Acids
The mTOR complex 1 (mTORC1) is a master regulator of cell growth and metabolism in response to environmental cues, such as nutrients. Its dysregulation is a common feature of several life-threatening disorders, including cancer and metabolic disease. Therefore, understanding how mTORC1 is regulated is of great importance for both basic and translational research. The availability of Amino Acids (AA) is a prerequisite for cell growth, hence a robust mTORC1 regulator. Previous studies on how AA regulate mTORC1 have mainly focused on the lysosomal Rag GTPases and built a complex protein network that coordinatively senses AA to modify Rag activity. According to the current model, AA sufficiency…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.