Wuite Lab

Research focus

ERC Advanced Grant · 2019

Disentangling metaphase chromosome organisation one chromosome at a time

Chromosomes assume their most compact state during metaphase just before they are separated. In this process of cell division the chromosomes experience high forces and genomic defects can occur then. Many techniques have built considerable understanding of metaphase chromosome structure and a multitude of models have been put forward how cells organize their chromosomes during metaphase. Yet, given the complexity of the process and limitations of the methods to study them, it is far from being fully understood. The breakthrough opportunity in this regard is the development of tools that allow real-time, 3D, super-resolution imaging and manipulation of entire non-fixed metaphase chromosomes…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.