ERC Advanced Grant · 2019
Identifying the steps required for meiotic DNA double-strand break formation
At the onset of prophase of the first meiotic division, meiotic cells undergo complex molecular events with the induction of several hundred DNA double-strand breaks. These DNA breaks are required because they initiate recombination between homologous chromosomes and to allow chromosome segregation during meiosis. They are essential for fertility. However, they represent a major challenge for genome integrity. It is thought that meiotic DNA break formation is under tight control to ensure that all breaks are properly repaired to maintain genome integrity. But how this control implemented is unknown. We postulate that three critical steps take place to ensure meiotic DNA break formation at…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.
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