ERC Consolidator Grant · 2019
Bridging temporal resolution gaps to dissect RNA silencing at the molecular and genomic scale
The implementation of distinct gene expression profiles is essential for organismal development, physiological responses to external stimuli or pathogens, and defines a primary cause for human disease. While much attention has been paid to the regulation of transcription, the control over RNA fate and function has only recently emerged as a central hallmark of gene regulation with enormous biological, technological and biomedical implications. Here, we propose to study the molecular principles of RNA silencing, the least understood aspect of post-transcriptional gene regulation. We aim to systematically dissect the mechanisms and biological functions of RNA 3´end uridylation to determine…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.