ERC Consolidator Grant · 2019
Structural basis of controlling the membrane attack complex
Structural basis of controlling the membrane attack complex Complement is a fundamental component of the human immune system; central to the battle between hosts and pathogens. The membrane attack complex (MAC) is the direct killing arm of complement that acts by forming large pores in target cell membranes. Uncontrolled activation results in by-stander damage, which can have devastating consequences for host cells and impact inflammatory pathologies, thrombosis and cancer. Understanding how MAC activity is controlled on human cells during an immune response is a major unresolved question. My lab has pioneered the use of cryo electron microscopy (cryoEM) to investigate the molecular…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.