ERC Starting Grant · 2019
Nucleolar Responses to DNA Damage: rDNA, an emerging hub of genome instability
DNA lesions can impose serious threats to genome integrity and cell viability. Whereas DNA damage may occur anywhere in the genome, it is increasingly recognized that certain genomic loci rich in repetitive sequences display increased susceptibility to damage and are linked to chromosomal rearrangements and malignancy. Clusters of ribosomal DNA gene (rDNA) repeats, present on five different chromosomes, constitute the most heavily transcribed area of the human genome and are organized in a nuclear membrane-less organelle, the nucleolus. So far, putative links between rDNA damage and malignant processes have not been rigorously assessed. Based on reported findings and preliminary…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.