Legube Lab

Research focus

ERC Advanced Grant · 2020

GENome and Epigenome integrity Consecutive to DSBs in Active REgion

DNA double-strand breaks (DSBs) are toxic lesions, holding the potential to generate mutations, copy number alterations and translocations. Beyond programmed DSBs induced during meiosis and antibody repertoire generation, DSBs were historically seen as rare, mostly therapy-induced DNA lesions. However, recent work unequivocally revealed that endogenous DSBs occur far more frequently that initially believed, including in physiological conditions, such as neuron stimulation, and mainly fall within transcribed loci, partly due to topoisomerase II activity. Notably, altered repair of these DSBs is not only emerging as a driver of oncogenesis but also of many developmental, neurological and…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.