ERC Advanced Grant · 2020
BRCA1, BRCA2 and associated factors are frequently mutated in familial and sporadic cancers of the breast and ovary. The BRCA proteins have canonical functions together with the RAD51 recombinase in DNA double-strand break repair by homologous recombination. More recently, it was discovered that the same proteins have separate, recombination-independent roles in the metabolism of challenged replication forks. It is currently debated whether defects in the canonical and/or non-canonical functions of BRCA contribute to tumorigenesis. As BRCA1 and BRCA2 function in various processes, interact with numbers of co-factors, and can be extensively post-translationally modified, phenotypes…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.
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