ERC Starting Grant · 2021
Sophisticated signalling systems enable bacteria to occupy almost every single niche on our planet. In such systems, second messengers are crucial information carriers that elicit cellular adaptation to diverse signals. Current dynamics in signalling research have led to the discovery of an exquisite collection of nucleotides that bacteria use as second messengers, including cyclic dimeric adenosine monophosphate (c-di-AMP). A unique feature of c-di-AMP is its essentiality, making it an attractive target for antibiotics. The main objective of this proposal is to uncover the full repertoire of c-di-AMP functions and metabolism in bacteria by using Streptomyces as a model. Streptomyces are…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.