ERC Advanced Grant · 2022
Ubiquitin-Proteasome System crosstalk with Metabolism
Cellular metabolites are essential components of life processes, and their import, biosynthesis, and enzymatic conversion are regulated by a wealth of pathways. The ubiquitin-proteasome system (UPS) plays a major role in ensuring that key metabolic regulators are maintained at proper levels, to control concentrations of ions, carbohydrates, amino acids, cofactors, and lipids. In particular, the activities and localization of critical ubiquitination enzymes (E3 ligases) and the proteasome must be tightly regulated to ensure that degradation is restricted to proteins that are unwanted, superfluous, or toxic, while sparing those proteins needed for ongoing metabolic functions. Nonetheless, we…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.