ERC Advanced Grant · 2022
When enzymes join forces: unmasking a mitochondrial biosynthetic engine
Enzymes have been classically investigated as standalone catalysts operating in a relatively diluted milieu. However, the cell micro-compartments are highly crowded environments and biological catalysis cannot be fully understood on the bases of simple diffusive models. We are tackling this challenge by reconstituting a full-scale biosynthetic pathway where multiple enzymes coordinate within a metabolon - a structurally defined setting that allows the vectorial transfer of substrates and products. Our system for exploration is the fascinating biosynthesis of coenzyme Q, an essential redox mediator for many pathways. The juxtaposition between its highly polar head group and hydrophobic tail…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.