ERC Advanced Grant · 2022
CTP-dependent molecular switches: an emerging new principle in cellular regulation
Nucleotide-dependent molecular switches play key roles in the regulation of cellular processes such as translation, protein folding and transport, cytoskeletal dynamics and cell differentiation. Until recently, their function was thought to rely exclusively on the purine nucleotides GTP or ATP as cofactors. This paradigm changed in 2019, when my group identified a fundamentally new class of regulatory switches, now called C-switches, that depend on the pyrimidine nucleotide CTP. The few C-switches studied to date have important functions in bacterial growth and pathogenicity. Database searches predict that C-switches are highly diverse and widespread in nature. However, the physiological…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.